Healthy Science/ Antioxidant Benefits of Vitamin E

Antioxidant Benefits of Vitamin E

  • Antioxidants help protect your cells from highly reactive molecules called free radicals
  • Oxidative stress from free radicals can lead to accelerated aging and cell damage
  • Vitamin E is a family of eight compounds with distinct health benefits and antioxidant effects

If you’re like most people, you probably think of scar healing when you think of vitamin E. And you’re not wrong—but you’re not right either. Although vitamin E is considered essential for skin health, the evidence linking it to scar healing is mostly anecdotal.1 What research does show, however, is that vitamin E boasts impressive antioxidative capacities that translate to more than just healthy skin.2,3 In this article, we talk about the importance of antioxidants, and how vitamin E in particular can help maintain oxidative balance in cells and tissues throughout the body. 

Antioxidants and Free Radicals: What are they and why do we need them?

Antioxidants are substances found in fruits and vegetables (and yes, certain other foods like dark chocolate) that help protect your cells from a chemical process called oxidation. Put simply, oxidation is any chemical reaction that involves the loss of electrons. More specifically, it is what happens when highly reactive and unstable molecules called free radicals steal electrons from other molecules.4

Free radicals are any molecules with an uneven number of electrons, which makes them highly reactive with other molecules. They are naturally formed by the body (for example, when we exercise or convert food to energy), but can also result from exposure to environmental sources such as air pollution, cigarette smoke, and sunlight.4,5 At low or moderate concentrations, free radicals are vital to human health, and can act as weapons for the immune system.6 However, when there are too many free radicals to be kept in balance by antioxidants, they can cause damage to lipids, proteins, and DNA in the body.46

For example, think of an apple. As soon as the flesh of an apple is exposed to oxygen in the air, it begins to turn brown. This is because oxygen atoms in the air interact with molecules in the apple to form reactive oxygen species (which include free radicals). These radicals start to break down the apple (i.e., oxidize it) and it begins to rot. Unfortunately, a similar process of oxidation and accelerated aging takes place in the body when cells are exposed to free radicals.4,5

This is not to say that oxidation is always bad. In fact, oxidation is a normal and necessary process for maintaining chemical balance throughout the body. It’s when the number of free radicals exceeds the number of antioxidants that oxidative stress becomes an issue.5,6 When this happens, an increase in antioxidants is needed to establish a state of oxidative balance (balance between the number of free radicals and antioxidants) in the body.  

Vitamin E Antioxidants 

Vitamin E is the collective name for a family of eight fat-soluble compounds that stop the production of reactive oxygen species when fat undergoes oxidation. You may be thinking, “That’s great—but do we really care what happens to fat?” The simple (and emphatic) answer is, “Yes!” 

Despite its less than stellar reputation, fat makes up most of the structural elements in our body’s trillions of cells and is necessary for cellular health and function. To name just one of its important functions, it helps form the lipid bilayer that regulates what enters and exits our cells. For this reason (and many others), protecting fats from oxidation with vitamin E antioxidants is key to preserving cellular function.3,6

Vitamin E Forms: Tocopherols and Tocotrienols 

The vitamin E family includes four tocopherols (alpha-, beta-, gamma-, and delta-tocopherol) and four tocotrienols (alpha-, beta-, gamma-, and delta-tocotrienol). In addition to being fat-soluble (meaning they can be stored in fatty tissues), tocopherols and tocotrienols have structural qualities that make them especially effective as antioxidants.7 All eight vitamin E forms are perfectly suited to associate with lipids in cell membranes while protecting them from oxidative damage. Each form possesses a long “root” that anchors them within the membrane lipids. Sticking out from this root is the “head” part of vitamin E, which is the antioxidant. 

Alpha-tocopherol is the predominant form of Vitamin E in the body, and the most common form found in vitamin E supplements. Thanks to its protective effect against the oxidation of polyunsaturated fatty acids (which are enriched in the membranes of immune cells), alpha-tocopherol plays an important role in regulating immune health.8,9 In addition to its well-established antioxidant actions, alpha-tocopherol supports healthy blood-clotting and can suppress enzyme activity involved in abnormal cell growth.10

Vitamin E Benefits Beyond Alpha-Tocopherol 

Despite being the most common form of vitamin E found in supplements, alpha-tocopherol is not the only form of vitamin E to provide health benefits.10 On the contrary, research shows that non-alpha tocopherols and tocotrienols provide unique functions that differ from alpha-tocopherol.7,10

  • Mixed tocopherols had a stronger inhibitory effect on lipid peroxidation and blood-clotting than alpha-tocopherol alone11,12
  • Gamma- and delta-tocopherols produced a greater inhibitory effect on abnormal cell growth than supplementation with alpha-tocopherol alone13,14
  • Tocotrienols possess neuroprotective, antioxidant, and cholesterol-lowering properties that differ from tocopherols7,15
  • Tocotrienols can enhance immune functions in the absence of tocopherols16,17

These findings underscore the importance of viewing vitamin E as a family of compounds and the value in supplementing with more than just alpha-tocopherol.

Distribution of Vitamin E Forms

But here’s where the plot thickens. Unlike the other vitamin E forms, alpha-tocopherol is preferentially distributed into circulation by the liver. This means that, in the presence of alpha-tocopherol, the majority of non-alpha tocopherols and tocotrienols are metabolized and eliminated from the body.18 Consequently, it is generally accepted that supplementation with tocotrienols and non-alpha-tocopherols should occur in the absence of alpha-tocopherol. However, this is less than ideal, given that different vitamin E forms provide different benefits and antioxidant effects. 

Fortunately, research indicates that vitamin E forms can maintain their biological activity when taken together, as long as alpha-tocopherol does not make up more than 25-30% of the total vitamin E content.19,20 Thus, finding a vitamin E complex providing the appropriate ratios of tocotrienols and tocopherols is highly important for maintaining a healthy response to oxidative stress. More specifically, look for a vitamin E complex offering a 4:1 ratio of tocotrienols:alpha-tocopherol.

Do I Need to Take a Vitamin E Supplement?

If you eat your fair share of green leafy vegetables, whole grains, nuts, seeds, and vegetable oils, you probably get enough vitamin E from your daily diet.  However, it is worth acknowledging that several national surveys indicate that the average American diet provides less than the recommended 15 mg of vitamin E per day.21,22 Concerns for vitamin E status are especially relevant for people with digestive issues or trouble absorbing fat, who are at a greater risk of vitamin E deficiency.23 If you think you may be at risk of vitamin E deficiency—or are someone who could benefit from additional antioxidant support—we encourage you to speak with a healthcare professional about whether taking a vitamin E supplement is right for you. 

Fat-soluble: Able to dissolve in fats or fat solvents; fat-soluble vitamins are absorbed along with fats in the diet and can be stored in the body’s fatty tissue.


Free radicals: Any molecule with an uneven number of electrons.


Lipid bilayer: A structure consisting of two layers of fat molecules organized in two sheets; the barrier that marks the boundaries of a cell and regulates what enters and exits.


Lipid peroxidation: A metabolic process in which free radicals steal electrons from the lipids, which causes damage to the lipid molecule.


Oxidation: A chemical process in which a molecule loses electrons.


Reactive oxygen species: A type of unstable molecule that contains oxygen and easily reacts with other molecules in a cell.


Tocopherols: A class of fat-soluble alcohols with vitamin E activity; includes four tocopherol isoforms (α-, β-, γ-, and δ-tocopherol).


Tocotrienols: A class of fat-soluble alcohols with vitamin E activity; includes four tocotrienol isoforms (α-, β-, γ-, and δ-tocotrienol).

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